Ulrich Helle D
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK.
Cell. 2007 Nov 2;131(3):446-7. doi: 10.1016/j.cell.2007.10.026.
Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.
缺氧，即严重的氧气短缺状况，会引发一种转录反应，这对于正常胚胎发育和肿瘤生长都很重要。在本期中，程等人（2007年）描述了缺氧反应的主要转录调节因子HIF1α的稳定性是如何通过泛素化和SUMO缀合系统之间的相互作用来调节的。
