胎盘生长激素相关蛋白和催乳素相关蛋白。

Placental growth hormone-related proteins and prolactin-related proteins.

作者信息

Haig D

机构信息

Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA.

出版信息

Placenta. 2008 Mar;29 Suppl A:S36-41. doi: 10.1016/j.placenta.2007.09.010. Epub 2007 Nov 5.

DOI:10.1016/j.placenta.2007.09.010

PMID:17981323

Abstract

The placentas of ruminants and muroid rodents express prolactin (PRL)-related genes whereas the placentas of anthropoid primates express growth hormone (GH)-related genes. The evolution of placental expression is associated with accelerated evolution of the corresponding pituitary hormone and destabilization of conserved endocrine systems. In particular, placental hormones often evolve novel interactions with new receptors. The adaptive functions of some placental hormones may be revealed only under conditions of physiological stress.

摘要

反刍动物和鼠类啮齿动物的胎盘表达催乳素（PRL）相关基因，而类人灵长类动物的胎盘表达生长激素（GH）相关基因。胎盘表达的进化与相应垂体激素的加速进化以及保守内分泌系统的不稳定有关。特别是，胎盘激素常常与新受体形成新的相互作用。某些胎盘激素的适应性功能可能只有在生理应激条件下才会显现出来。