Antuna-Puente Barbara, Feve Bruno, Fellahi Soraya, Bastard Jean-Philippe
INSERM U680, Faculté de Médecine Saint-Antoine, Université Pierre et Marie Curie, Paris 6, Paris, France.
Therapie. 2007 Jul-Aug;62(4):285-92. doi: 10.2515/therapie:2007055. Epub 2007 Nov 6.
Adipose tissue is now recognized as an endocrine organ involved in regulating physiologic and pathologic processes including inflammation. It synthesizes and secretes hormones such as leptin and adiponectin. It can secrete other products namely adipokines including cytokines and chemokines. The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic sub-inflammatory state that likely plays a major role in cardiovascular complications linked to obesity and insulin resistance.
脂肪组织现在被认为是一种内分泌器官，参与调节包括炎症在内的生理和病理过程。它合成并分泌瘦素和脂联素等激素。它还能分泌其他产物，即脂肪因子，包括细胞因子和趋化因子。脂肪细胞或浸润脂肪组织的巨噬细胞释放脂肪因子会导致慢性亚炎症状态，这可能在与肥胖和胰岛素抵抗相关的心血管并发症中起主要作用。
