神经影像学：基因、大脑与行为交叉领域的技术
Neuroimaging: technologies at the interface of genes, brain, and behavior.
作者信息
Bigos Kristin L, Hariri Ahmad R
机构信息
Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA.
出版信息
Neuroimaging Clin N Am. 2007 Nov;17(4):459-67, viii. doi: 10.1016/j.nic.2007.09.005.
Abstract
Neuroimaging technologies provide a powerful approach to exploring the genetic basis of individual differences in complex behaviors and vulnerability to neuropsychiatric illness. Functional MRI studies have established important physiologic links between genetic polymorphisms and robust differences in information processing within distinct brain regions and circuits that have been linked to the manifestation of various disease. Neuroimaging technologies represent a critical tool in efforts to understand the neurobiology of normal and pathologic behavioral states. Research capitalizing on neuroimagingbased integration will contribute to the identification of predictive markers and biologic pathways for neuropsychiatric disease vulnerability and the generation of novel targets for therapeutic intervention.
摘要
神经成像技术为探索复杂行为个体差异的遗传基础以及神经精神疾病易感性提供了一种强大的方法。功能磁共振成像研究已经在基因多态性与不同脑区和神经回路中信息处理的显著差异之间建立了重要的生理联系，这些脑区和神经回路与各种疾病的表现有关。神经成像技术是理解正常和病理行为状态神经生物学的关键工具。利用基于神经成像的整合研究将有助于识别神经精神疾病易感性的预测标志物和生物学途径，并为治疗干预产生新的靶点。
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