Eskandar Kirolos
Helwan University, Faculty of Medicine and Surgery, Egypt.
Glob Med Genet. 2025 Feb 20;12(2):100043. doi: 10.1016/j.gmg.2025.100043. eCollection 2025 Jun.
The stability and satisfaction of sexual relationships are critical determinants of individual well-being and societal cohesion. While much is known about the psychological and social factors influencing these outcomes, the genetic underpinnings remain an emerging field of inquiry. This literature review synthesizes findings from 42 peer-reviewed studies published between 2003 and 2023, exploring the genetic contributions to relationship stability and satisfaction. Key findings indicate that neuroticism, with an estimated heritability of ∼40 %, is a strong predictor of relationship instability, while agreeableness and extraversion are associated with greater relationship satisfaction. The review examines the genetic foundations of personality traits, attachment styles, emotional regulation, hormonal influences, sexual compatibility, communication styles, and mental health predispositions. Additionally, it highlights the interplay between genetic and environmental factors, presenting case studies and empirical evidence that elucidate the complex interactions at play. Ethical considerations and future research directions are discussed to provide a comprehensive understanding of how genetics can shape successful sexual relationships. By bridging the gap between genetic research and relationship science, this review offers data-driven insights to guide future investigations in this interdisciplinary domain.
性关系的稳定性和满意度是个体幸福感和社会凝聚力的关键决定因素。虽然我们对影响这些结果的心理和社会因素了解很多，但基因基础仍是一个新兴的研究领域。这篇文献综述综合了2003年至2023年间发表的42项同行评议研究的结果，探讨了基因对关系稳定性和满意度的贡献。主要研究结果表明，神经质的遗传率约为40%，是关系不稳定的有力预测指标，而宜人性和外向性则与更高的关系满意度相关。该综述考察了人格特质、依恋风格、情绪调节、激素影响、性相容性、沟通方式和心理健康倾向的基因基础。此外，它还强调了基因和环境因素之间的相互作用，展示了阐明其中复杂相互作用的案例研究和实证证据。文中讨论了伦理考量和未来研究方向，以全面理解基因如何塑造成功的性关系。通过弥合基因研究与关系科学之间的差距，本综述提供了数据驱动的见解，以指导该跨学科领域的未来研究。
