[地中海贫血中的核磁共振与铁过载]

[Nuclear magnetic resonance and iron overload in thalassemia].

作者信息

Schettini F, De Mattia D, Cavallo L, Sabato V, Santoro N, Del Vecchio G C, Martinelli G, Martinelli A, Di Bartolomeo P, Di Girolamo G

机构信息

Istituto di Pediatria Clinica e Preventiva, Università di Bari.

出版信息

Minerva Pediatr. 1991 Dec;43(12):777-81.

PMID:1798402

Abstract

We assessed the iron load content in 36 beta-thalassemia patients by NMR correlating the results with serum ferritin levels. 22 of them were affected by beta-thalassemia major on hyper-transfusional regimen (Group A), 4 by beta-thalassemia intermedia (Group B) and 10 by beta-thalassemia major, who had been previously bone marrow transplanted (Group C). In A and C Groups the liver showed the lowest signal intensity on spin echo images (p less than 0.01; p less than 0.06, respectively). A significant correlation between the summation of signals obtained from all the examined organs and serum ferritin levels was observed by evaluating both all the patients globally (r = 0.78; p less than 0.001) and the A and C Group patients. This correlation was confirmed only in the liver both in all the patients (r = 0.77; p less than 0.001) and in A and C Group patients, when the signals obtained from each organ were evaluated.

摘要

我们通过核磁共振评估了36例β地中海贫血患者的铁负荷含量，并将结果与血清铁蛋白水平相关联。其中22例为重型β地中海贫血且采用强化输血方案（A组），4例为中间型β地中海贫血（B组），10例为重型β地中海贫血且曾接受过骨髓移植（C组）。在A组和C组中，肝脏在自旋回波图像上显示出最低信号强度（分别为p<0.01；p<0.06）。通过对所有患者整体评估（r = 0.78；p<0.001）以及对A组和C组患者评估发现，从所有检查器官获得的信号总和与血清铁蛋白水平之间存在显著相关性。当对每个器官获得的信号进行评估时，这种相关性仅在所有患者的肝脏中（r = 0.77；p<0.001）以及A组和C组患者的肝脏中得到证实。