Montagna O, Giusti A, Baisi F, Napolitano L, Mautone A
Istituto di Pediatria Clinica e Preventiva, Università degli Studi di Bari.
Minerva Pediatr. 1991 Dec;43(12):793-6.
The premature rupture of the membranes is still a cause of concern due to the related risk of infection and respiratory disorders. The study included sixty-two neonates whose mothers had ruptured their membranes for at least 48 hours (group A) and 42 neonates with a high risk of infection (low birth weight, prematurity) (group B) in order to assess whether antibiotic prophylaxis used in pregnant women with premature rupture of the membranes is sufficient to reduce the risk of severe neonatal infection. The results obtained show that there is an increased frequency of RDS, jaundice and mortality in group A, whereas in group B there was a greater frequency of sepsis and urinary tract infections. Antibiotic prophylaxis therefore allows the frequency of neonatal infections following the rupture of membranes to be reduced, thus enabling the birth to be delayed in order to induce pulmonary maturity.
胎膜早破仍是一个令人担忧的问题,因为它存在感染和呼吸系统疾病的相关风险。该研究纳入了62例母亲胎膜破裂至少48小时的新生儿(A组)和42例有感染高风险(低出生体重、早产)的新生儿(B组),以评估胎膜早破孕妇使用抗生素预防是否足以降低严重新生儿感染的风险。获得的结果表明,A组呼吸窘迫综合征、黄疸和死亡率的发生率增加,而B组败血症和尿路感染的发生率更高。因此,抗生素预防可降低胎膜破裂后新生儿感染的发生率,从而能够延迟分娩以促进肺成熟。