Bowes Jeff B, Snyder Kevin A, Segerdell Erik, Gibb Ross, Jarabek Chris, Noumen Etienne, Pollet Nicolas, Vize Peter D
Department of Computer Science, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada.
Nucleic Acids Res. 2008 Jan;36(Database issue):D761-7. doi: 10.1093/nar/gkm826. Epub 2007 Nov 4.
Xenbase (www.xenbase.org) is a model organism database integrating a diverse array of biological and genomic data on the frogs, Xenopus laevis and Xenopus (Silurana) tropicalis. Data is collected from other databases, high-throughput screens and the scientific literature and integrated into a number of database modules covering subjects such as community, literature, gene and genomic analysis. Gene pages are automatically assembled from data piped from the Entrez Gene, Gurdon Institute, JGI, Metazome, MGI, OMIM, PubMed, Unigene, Zfin, commercial suppliers and others. These data are then supplemented with in-house annotation. Xenbase has implemented the Gbrowse genome browser and also provides a BLAST service that allows users to specifically search either laevis or tropicalis DNA or protein targets. A table of Xenopus gene synonyms has been implemented and allows the genome, genes, publications and high-throughput gene expression data to be seamlessly integrated with other Xenopus data and to external database resources, making the wealth of developmental and functional data from the frog available to the broader research community.
非洲爪蟾数据库（www.xenbase.org）是一个模式生物数据库，整合了关于非洲爪蟾（Xenopus laevis）和热带爪蟾（Xenopus (Silurana) tropicalis）的各种生物学和基因组数据。数据从其他数据库、高通量筛选以及科学文献中收集，并整合到多个数据库模块中，涵盖社区、文献、基因和基因组分析等主题。基因页面由来自Entrez基因数据库、格登研究所、联合基因组研究所、Metazome、小鼠基因组数据库、在线孟德尔人类遗传数据库、PubMed、单基因数据库、斑马鱼信息网络、商业供应商等的数据自动组装而成。然后，这些数据会补充内部注释。非洲爪蟾数据库已实施了Gbrowse基因组浏览器，还提供了BLAST服务，允许用户专门搜索非洲爪蟾或热带爪蟾的DNA或蛋白质靶点。现已建立了非洲爪蟾基因同义词表，使基因组、基因、出版物和高通量基因表达数据能够与其他非洲爪蟾数据以及外部数据库资源无缝整合，从而让更广泛的研究群体能够获取来自青蛙的丰富发育和功能数据。
