Chanda Dipanjan, Park Jeong-Hoh, Choi Hueng-Sik
Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.
Endocr J. 2008 May;55(2):253-68. doi: 10.1507/endocrj.k07e-103. Epub 2007 Nov 2.
Nuclear receptors (NRs) are a unique superfamily of transcription factors (TFs) which are involved in and play a crucial role in almost all aspects of mammalian physiology. Small Heterodimer Partner (SHP; NR0B2), an exceptional member of this superfamily of NRs, have been identified as a key regulatory factor of the transcription of a variety of genes involved in diverse metabolic pathways, and are thereby an important factor in a variety of physiological functions. Since its discovery a decade ago, considerable progress has been made in the elucidation of the underlying mechanism by which SHP regulates various metabolic processes, and the results of previous studies support its importance in the maintenance of metabolic homeostasis. In this review, we have evaluated the current state of understanding of the molecular mechanisms and the resultant physiological interpretations governed by SHP.
核受体（NRs）是一类独特的转录因子（TFs）超家族，几乎参与哺乳动物生理学的各个方面并发挥关键作用。小异源二聚体伴侣蛋白（SHP；NR0B2）是该核受体超家族中的一个特殊成员，已被确定为参与多种代谢途径的各种基因转录的关键调节因子，因此也是多种生理功能中的重要因子。自十年前被发现以来，在阐明SHP调节各种代谢过程的潜在机制方面已经取得了相当大的进展，先前的研究结果支持其在维持代谢稳态中的重要性。在这篇综述中，我们评估了目前对SHP所调控的分子机制及其相应生理意义的理解现状。
