莫桑比克农村地区五岁以下儿童志贺菌病的流行病学与临床表现
Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique.
作者信息
Mandomando Inácio, Sigaúque Betuel, Vallès Xavier, Espasa Mateu, Sanz Sergi, Sacarlal Jahit, Macete Eusébio, Abacassamo Fátima, Ruiz Joaquim, Gascon Joaquim, Kotloff Karen L, Levine Myron M, Alonso Pedro L
机构信息
Centro de Investigação em Saúde da Manhiça, IDIBAPS/Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
出版信息
Pediatr Infect Dis J. 2007 Nov;26(11):1059-61. doi: 10.1097/INF.0b013e31812e55a2.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical findings. Shigella was more frequently isolated from cases than controls (6.7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes.
从曼希卡地区医院就诊的1354名5岁以下腹泻儿童以及227名健康社区对照中采集直肠拭子。志贺氏菌病发病率在12 - 47个月大的儿童中较高（每10⁵儿童年发病风险为488.4例）。发热和痢疾是突出的临床症状。志贺氏菌在病例中比在对照中更频繁地分离出来（6.7%对0.4%，P = 0.004），在痢疾患者中比在非痢疾性腹泻患者中更频繁地分离出来（24.1%对3.5%，P < 0.001）。福氏志贺氏菌2a、宋内志贺氏菌和福氏志贺氏菌6是最常见的血清型。
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