Vubil Delfino, Acácio Sozinho, Quintò Llorenç, Ballesté-Delpierre Clara, Nhampossa Tacilta, Kotloff Karen, Levine Myron M, Alonso Pedro, Nataro James P, Farag Tamer H, Vila Jordi, Mandomando Inacio
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique,
Instituto Nacional de Saúde (INS), Maputo, Mozambique,
Infect Drug Resist. 2018 Oct 31;11:2095-2106. doi: 10.2147/IDR.S177579. eCollection 2018.
During the period from December 2007 to November 2012, the epidemiology of diarrhea caused by was studied among children <5 years of age residing in Manhiça District, Southern Mozambique.
Children from 0 to 5 years with moderate-to-severe diarrhea (MSD) and less severe diarrhea (LSD) were enrolled along with matched controls (by age, gender, and neighborhood). Age-stratified logistic regression analyses were conducted to identify clinical features and risk factors associated with positivity in cases of diarrhea. The impact of antibiotic treatment was assessed for patients with known outcome.
A total of 916 cases of MSD and 1979 matched controls, and 431 cases of LSD with equal number of controls were enrolled. was identified as significant pathogen in both cases of MSD and LSD compared to their respective controls. was detected in 3.9% (17/431) of LSD compared to 0.5% (2/431) in controls (=0.001) and in 6.1% (56/916) of MSD cases compared to 0.2% (4/1979) in controls (<0.0001), with an attributable fraction of 8.55% (95% CI: 7.86-9.24) among children aged 12-23 months. Clinical symptoms associated to among MSD cases included dysentery, fever, and rectal prolapse. Water availability, giving stored water to child, washing hands before preparing baby's food, and mother as caretaker were the protective factors against acquiring diarrhea caused by . Antibiotic treatment on admission was associated with a positive children outcome.
remains a common pathogen associated with childhood diarrhea in Mozambique, with dysentery being a significant clinical feature of shigellosis. Adherence to the basic hygiene rules and the use of antibiotic treatment could contribute to the prevention of most of diarrhea due to .
在2007年12月至2012年11月期间，对莫桑比克南部曼希卡区5岁以下儿童中由[病原体名称未给出]引起的腹泻流行病学进行了研究。
纳入0至5岁患有中重度腹泻（MSD）和轻度腹泻（LSD）的儿童以及匹配的对照组（按年龄、性别和邻里匹配）。进行年龄分层的逻辑回归分析，以确定腹泻病例中与[病原体名称未给出]阳性相关的临床特征和危险因素。对已知结局的患者评估抗生素治疗的影响。
共纳入916例MSD病例和1979例匹配的对照组，以及431例LSD病例和数量相等的对照组。与各自的对照组相比，[病原体名称未给出]在MSD和LSD病例中均被确定为重要病原体。LSD病例中3.9%（17/431）检测到[病原体名称未给出]，而对照组为0.5%（2/431）（P = 0.001）；MSD病例中6.1%（56/916）检测到[病原体名称未给出]，而对照组为0.2%（4/1979）（P < 0.0001），在12至23个月大的儿童中归因分数为8.55%（95% CI：7.86 - 9.24）。MSD病例中与[病原体名称未给出]相关的临床症状包括痢疾、发热和直肠脱垂。水源可及性、给儿童饮用储存水、在准备婴儿食物前洗手以及母亲作为照顾者是预防由[病原体名称未给出]引起腹泻的保护因素。入院时使用抗生素治疗与儿童良好结局相关。
[病原体名称未给出]仍然是莫桑比克与儿童腹泻相关的常见病原体，痢疾是志贺菌病的重要临床特征。遵守基本卫生规则和使用抗生素治疗有助于预防大多数由[病原体名称未给出]引起的腹泻。
