Klöppel Günter, Anlauf Martin
Department of Pathology, University of Kiel, Kiel, Germany.
Wien Klin Wochenschr. 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1.
Gastrinomas are defined as gastrin producing tumors that are associated with an elevated fasting gastrin serum level, a positive gastrin secretin stimulation test and certain clinical symptoms, e.g. recurrent peptic ulcer disease and occasionally diarrhea, the so-called Zollinger-Ellison syndrome. Most gastrinomas occur in the duodenum (approx. 70%) and not in the pancreas. The duodenal gastrinomas are small, and when they occur in association with the genetic syndrome of multiple endocrine neoplasia type 1 (MEN1), they are multicentric and originate from precursor lesions. The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis.
胃泌素瘤被定义为产生胃泌素的肿瘤，其与空腹血清胃泌素水平升高、胃泌素促胰液素刺激试验阳性以及某些临床症状相关，例如复发性消化性溃疡疾病，偶尔还有腹泻，即所谓的卓-艾综合征。大多数胃泌素瘤发生在十二指肠（约70%）而非胰腺。十二指肠胃泌素瘤较小，当它们与1型多发性内分泌肿瘤（MEN1）的遗传综合征相关时，它们是多中心的，起源于前体病变。十二指肠胃泌素瘤的预后优于胰腺胃泌素瘤，因为尽管早期有淋巴结转移，但它们进展缓慢，会发生肝转移。
