Van den Bruel A, Moreno-Reyes R, Bex M, Daumerie C, Glinoer D
Department of Internal Medicine/Endocrinology, AZ Brugge, Ruddershove 10, 8000 Brugge, Belgium.
Clin Endocrinol (Oxf). 2008 Apr;68(4):599-604. doi: 10.1111/j.1365-2265.2007.03092.x. Epub 2007 Nov 6.
To assess approaches to patients with a potentially malignant thyroid nodule and patients with differentiated thyroid carcinoma and compare them with the European Consensus and Guidelines by the American Thyroid Association.
A survey of the 388 active members of the Belgian Thyroid Club.
A questionnaire addressing the management of an index case and four clinical variations (including variations in the size of the tumour and histological type). The index case was a 40-year-old euthyroid woman with a 3-cm solitary thyroid nodule. Fine-needle aspiration (FNA) cytology showed cellular aspirates with numerous follicular cells and no colloid.
The overall response rate was 41%. For the index case, respondents favoured a right lobectomy. Variations in size and histopathology of the nodule altered the management. In the case of a papillary thyroid carcinoma (PTC) of 3 cm in diameter, a total thyroidectomy and prophylactic central lymph node dissection was preferred. After a lobectomy showing a 3.5-cm follicular thyroid carcinoma (FTC), completion surgery followed by radioiodine administration was the most frequent proposal. For the follow-up of the index case with a low-risk disease, determination of serum thyroglobulin (Tg) after recombinant human TSH (rhTSH) administration was considered by the majority of respondents. For the follow-up of a clinical variation with residual disease, immediate planning of a new treatment was (mistakenly) not considered by a majority of respondents.
In most cases, respondents were in accordance with the guidelines, although there were some unexpected variations.
评估对潜在恶性甲状腺结节患者和分化型甲状腺癌患者的治疗方法,并将其与欧洲共识及美国甲状腺协会指南进行比较。
对比利时甲状腺俱乐部388名活跃成员进行调查。
一份针对一个索引病例及四种临床变异情况(包括肿瘤大小和组织学类型的变异)的调查问卷。索引病例为一名40岁甲状腺功能正常的女性,有一个3厘米的孤立性甲状腺结节。细针穿刺(FNA)细胞学检查显示细胞涂片中有大量滤泡细胞且无胶质。
总体回复率为41%。对于索引病例,受访者倾向于行右叶切除术。结节大小和组织病理学的变异改变了治疗方案。对于直径3厘米的乳头状甲状腺癌(PTC)病例,首选全甲状腺切除术和预防性中央淋巴结清扫术。在叶切除术后显示为3.5厘米的滤泡状甲状腺癌(FTC)时,最常见的建议是完成手术并给予放射性碘治疗。对于索引病例低风险疾病的随访,大多数受访者认为在给予重组人促甲状腺激素(rhTSH)后测定血清甲状腺球蛋白(Tg)。对于有残留疾病的临床变异情况的随访,大多数受访者(错误地)未考虑立即规划新的治疗方案。
在大多数情况下,受访者符合指南,尽管存在一些意外的变异情况。