药物对精子发生的影响。

Drug effects on spermatogenesis.

作者信息

Amory John K

机构信息

Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

出版信息

Drugs Today (Barc). 2007 Oct;43(10):717-24. doi: 10.1358/dot.2007.43.10.1131829.

DOI:10.1358/dot.2007.43.10.1131829

PMID:17987224

Abstract

Many drugs can adversely affect spermatogenesis. These effects can occur either by directly inhibiting sperm or testicular function or indirectly by impairing the hypothalamic pituitary testicular axis. In this paper, we will review the drugs that are known to adversely impact spermatogenesis, and/or sperm function and detail what is known about the mechanisms through which these compounds impair fertility in men.

摘要

许多药物会对精子发生产生不利影响。这些影响可能通过直接抑制精子或睾丸功能，或通过损害下丘脑 - 垂体 - 睾丸轴间接发生。在本文中，我们将综述已知对精子发生和/或精子功能有不利影响的药物，并详细阐述这些化合物损害男性生育能力的机制。