天然存在的肽及其类似物的合成。

The synthesis of naturally occurring peptides and their analogs.

作者信息

Cupido Tommaso, Tulla-Puche Judit, Spengler Jan, Albericio Fernando

机构信息

Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1-5, Barcelona, Spain.

出版信息

Curr Opin Drug Discov Devel. 2007 Nov;10(6):768-83.

PMID:17987528

Abstract

The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.

摘要

近年来，基于肽的药物数量大幅增加；其中一些肽源自天然来源，且许多肽分子量大且结构复杂。本综述概述了肽合成方法的当前状况，主要聚焦于天然肽及其类似物的合成。