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以糖精为氮源，钛-超氧化物催化醛的氧化酰胺化反应：伯酰胺的合成

Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides.

作者信息

Kamble Rohit B, Mane Kishor D, Rupanawar Bapurao D, Korekar Pranjal, Sudalai A, Suryavanshi Gurunath

机构信息

Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory Pune Maharashtra India-411 008

Academy of Scientific and Innovative Research Ghaziabad UP India-201002.

出版信息

RSC Adv. 2020 Jan 2;10(2):724-728. doi: 10.1039/c9ra10413e.

DOI:10.1039/c9ra10413e
PMID:35494431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9047451/
Abstract

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

摘要

一种新型的多相催化体系（钛超氧化物/糖精/叔丁基过氧化氢）已被开发出来，该体系能高效催化醛的氧化酰胺化反应，以生产各种伯酰胺。该方法采用糖精作为胺源，并且发现它能耐受具有不同官能团的多种底物。中等至优异的产率、催化剂的可重复使用性和操作简便性是其主要亮点。此外，还讨论了氧化酰胺化反应中可能的机理以及催化剂的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/cf5e23ac94c1/c9ra10413e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/cc7bcd0ee7db/c9ra10413e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/b3059e85be3e/c9ra10413e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/8981182fb156/c9ra10413e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/7f0e61581838/c9ra10413e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/30048c00f41e/c9ra10413e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/cf5e23ac94c1/c9ra10413e-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/cc7bcd0ee7db/c9ra10413e-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/b3059e85be3e/c9ra10413e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/8981182fb156/c9ra10413e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/7f0e61581838/c9ra10413e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/30048c00f41e/c9ra10413e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e357/9047451/cf5e23ac94c1/c9ra10413e-f2.jpg

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本文引用的文献

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Org Lett. 2019 Dec 20;21(24):9841-9845. doi: 10.1021/acs.orglett.9b03682. Epub 2019 Dec 12.
2
tert-Butyl peroxide (TBHP)/KI-mediated dual C(sp)-H bond amination of arylamines with α-diazo carbonyls toward 1,2,4-benzotriazines.叔丁基过氧化物（TBHP）/碘化钾介导的芳胺与α-重氮羰基化合物的双 C(sp)-H 键氨化反应生成 1,2,4-苯并三嗪。
Chem Commun (Camb). 2019 Oct 31;55(88):13231-13234. doi: 10.1039/c9cc07236e.
3
Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: effective conversion of amines and anilines into amides.
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Chem Sci. 2016 Feb 1;7(2):969-975. doi: 10.1039/c5sc03103f. Epub 2015 Oct 27.
4
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Angew Chem Int Ed Engl. 2001 Jan 19;40(2):405-408. doi: 10.1002/1521-3773(20010119)40:2<405::AID-ANIE405>3.0.CO;2-6.
5
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Chem Sci. 2017 Oct 24;9(2):380-386. doi: 10.1039/c7sc04054g. eCollection 2018 Jan 14.
6
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