瘦素对链脲佐菌素诱导的糖尿病大鼠肾上腺的影响：一项实验研究。
The effect of leptin on adrenal glands in rats with streptozotocin-induced diabetes: an experimental study.
作者信息
Ergin Kemal, Aktuğ Hüseyin, Başloğlu Hulki, Başaloğlu Hatice Kübra, Yilmaz Mahmut Ilker, Turgut Mehmet
机构信息
Department of Embryology and Histology, Adnan Menderes University School of Medicine, Aydin, Turkey.
出版信息
Anal Quant Cytol Histol. 2007 Oct;29(5):291-5.
OBJECTIVE
To determine the cross-section area of adrenal medulla and the percentage of Ki-67 (a proliferation marker) of the adrenal gland in diabetic rats after leptin injection.
STUDY DESIGN
Twenty-nine male Wistar rats were randomly divided into 3 groups: control (C) group (n = 9), diabetes mellitus (DM) group (n = 10) and leptin-injected diabetes mellitus (DM+L) group (n = 10). Experimental DM was induced by a single intraperitoneal dose of streptozotocin (40 mg/kg). After this, leptin (100 microg/kg) was injected subcutaneously for a period of 2 weeks in the diabetic group.
RESULTS
An atrophy of adrenal medulla in the DM group was observed, and this atrophy returned to normal morphology after injection of leptin. In addition, an increase in the Ki-67 percentage was demonstrated in the zona reticularis layers in the DM+L group.
CONCLUSION
Our study indicated that leptin stimulates the sympathoadrenal system and the androgen producing adrenal cortex in DM rats.
目的
确定注射瘦素后糖尿病大鼠肾上腺髓质的横截面积以及肾上腺中增殖标志物Ki-67的百分比。
研究设计
将29只雄性Wistar大鼠随机分为3组：对照组（C组，n = 9）、糖尿病组（DM组，n = 10）和注射瘦素的糖尿病组（DM + L组，n = 10）。通过单次腹腔注射链脲佐菌素（40 mg/kg）诱导实验性糖尿病。此后，在糖尿病组中皮下注射瘦素（100 μg/kg），持续2周。
结果
观察到DM组肾上腺髓质萎缩，注射瘦素后这种萎缩恢复到正常形态。此外，DM + L组网状带层的Ki-67百分比增加。
结论
我们的研究表明，瘦素刺激糖尿病大鼠的交感肾上腺系统和产生雄激素的肾上腺皮质。
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