Wang Hong-zhen, Wang Hai-bin, Gao Hong
Department of Oncology, Rizhao Municipal Hospital of Traditional Chinese Medicine, Shandong.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Oct;27(10):927-9.
To evaluate the therapeutic and adverse reactions of integrative Chinese and Western medicine (ICWM) for treatment of advanced gastric carcinoma.
Sixty-six patients with advanced gastric carcinoma were randomized into two groups. Patients in the treatment group (34 patients) received chemotherapy of DCF (docetaxel/cisplatin/5-fluorouracil) regimen combined with Chinese herbal medicine, and patients in the control group (32 patients) were treated with chemotherapy of the same regimen alone.
No significant difference between the two groups was found in response rate (55.9% versus 50.0%), clinical benefiting rate (85.3% versus 81.3%) and half year survival rate (82.4% versus 65.6%); but the 1-year survival rate in the treatment group was superior to that in the control group (52.9% versus 25.0% , P < 0.05). As for the adverse reactions, significant difference between the two groups was shown in incidence of leucopenia, nausea and vomiting, mucosa reaction and fatigue, these reactions occurred lesser in the treatment group (P< 0.05).
Although treatment of ICWM for advanced gastric carcinoma cannot improve response rate, it could alleviate the adverse reactions of the treatment, improve quality of life and prolong the survival rate in patients.
评估中西医结合治疗晚期胃癌的疗效及不良反应。
将66例晚期胃癌患者随机分为两组。治疗组（34例）采用多西他赛/顺铂/5-氟尿嘧啶（DCF）方案化疗联合中药治疗，对照组（32例）单纯采用相同方案化疗。
两组有效率（55.9%对50.0%）、临床受益率（85.3%对81.3%）及半年生存率（82.4%对65.6%）比较，差异无统计学意义；但治疗组1年生存率优于对照组（52.9%对25.0%，P<0.05）。不良反应方面，两组白细胞减少、恶心呕吐、黏膜反应及乏力发生率比较，差异有统计学意义，治疗组上述反应发生率较低（P<0.05）。
中西医结合治疗晚期胃癌虽不能提高有效率，但可减轻治疗不良反应，提高患者生活质量，延长生存期。
