抗体抵御西尼罗河病毒的分子基础。

The molecular basis of antibody protection against West Nile virus.

作者信息

Mehlhop E, Diamond M S

机构信息

Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St. Louis, MO 63110, USA.

出版信息

Curr Top Microbiol Immunol. 2008;317:125-53. doi: 10.1007/978-3-540-72146-8_5.

DOI:10.1007/978-3-540-72146-8_5

PMID:17990792

Abstract

West Nile virus (WNV) infection of mosquitoes, birds, and vertebrates continues to spread in the Western Hemisphere. In humans, WNV infects the central nervous system and causes severe disease, primarily in the immunocompromised and elderly. In this review we discuss the mechanisms by which antibody controls WNV infection. Recent virologic, immunologic, and structural experiments have enhanced our understanding on how antibodies neutralize WNV and protect against disease. These advances have significant implications for the development of novel antibody-based therapies and targeted vaccines.

摘要

西尼罗河病毒（WNV）在蚊子、鸟类和脊椎动物中的感染仍在西半球持续蔓延。在人类中，WNV感染中枢神经系统并引发严重疾病，主要发生在免疫功能低下者和老年人身上。在本综述中，我们讨论了抗体控制WNV感染的机制。最近的病毒学、免疫学和结构实验增进了我们对抗体如何中和WNV并预防疾病的理解。这些进展对新型抗体疗法和靶向疫苗的开发具有重要意义。