Immunology Unit, Institut Pasteur du Cambodge, Pasteur Network, Phnom Penh, Cambodia.
Department of Immunology, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Emerg Microbes Infect. 2024 Dec;13(1):2304061. doi: 10.1080/22221751.2024.2304061. Epub 2024 Jan 25.
Mosquito-borne viral infections are on the rise worldwide and can lead to severe symptoms such as haemorrhage, encephalitis, arthritis or microcephaly. A protective immune response following mosquito-borne viral infections requires the generation of a controlled and balanced immune response leading to viral clearance without immunopathology. Here, regulatory T cells play a central role in restoring immune homeostasis. In current review, we aim to provide an overview and summary of the phenotypes of FOXP3 Tregs in various mosquito-borne arboviral disease, their association with disease severity and their functional characteristics. Furthermore, we discuss the role of cytokines and Tregs in the immunopathogenesis of mosquito-borne infections. Lastly, we discuss possible novel lines of research which could provide additional insight into the role of Tregs in mosquito-borne viral infections in order to develop novel therapeutic approaches or vaccination strategies.
蚊媒病毒感染在全球呈上升趋势，可导致严重症状，如出血、脑炎、关节炎或小头畸形。蚊媒病毒感染后产生的保护性免疫反应需要生成一种受控和平衡的免疫反应，从而在不引起免疫病理学的情况下清除病毒。在这里，调节性 T 细胞在恢复免疫平衡方面发挥着核心作用。在本综述中，我们旨在概述和总结各种蚊媒虫媒病毒病中 FOXP3+Tregs 的表型、它们与疾病严重程度的关联以及它们的功能特征。此外，我们还讨论了细胞因子和 Tregs 在蚊媒感染免疫发病机制中的作用。最后，我们讨论了可能的新研究方向，这些方向可以为 Tregs 在蚊媒病毒感染中的作用提供更多的见解，从而开发新的治疗方法或疫苗策略。
