Grynspan David, Lukacik Marek, Madani Shailender, Poulik Janet
Department of Pathology, Children's Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201, USA.
Pediatr Dev Pathol. 2008 May-Jun;11(3):235-8. doi: 10.2350/07-04-0266.1. Epub 2007 Jul 16.
Hyperplastic esophagogastric polyps usually occur in the distal esophagus or gastroesophageal junction and have been associated with damage to the esophageal mucosa. Histologically these polyps show hyperplastic gastric foveolar and/or squamous epithelium with inflamed stroma. Reports of esophagogastric polyps in the pediatric population are rare. Most of these reports only describe chronic inflammation within the lamina propria of the polyp, with only rare reports specifying the presence of epithelial hyperplasia. There have been 2 previous cases of hyperplastic esophagogastric polyps occurring in the context of neurofibromatosis type 1 (NF-1) in a single article. Here we report a 3rd case of hyperplastic esophagogastric polyps occurring in an 11-year-old male with NF-1. This case is unique in that there were 2 polyps in the same patient and in that the polyps showed hyperplastic gastric peptic glands in addition to foveolar-type and focal squamous epithelium. The case is discussed and literature reviewed.
增生性食管胃息肉通常发生在食管远端或胃食管交界处，与食管黏膜损伤有关。从组织学上看，这些息肉表现为增生的胃小凹和/或鳞状上皮，伴有炎症性间质。儿科人群中食管胃息肉的报道很少。这些报道大多只描述了息肉固有层内的慢性炎症，只有极少数报道明确指出存在上皮增生。在一篇文章中，此前曾有2例1型神经纤维瘤病（NF-1）患者发生增生性食管胃息肉的病例。在此，我们报告1例11岁患NF-1的男性发生增生性食管胃息肉的第3个病例。该病例的独特之处在于，同一患者有2个息肉，且息肉除了有小凹型和局灶性鳞状上皮外，还显示有增生的胃消化腺。本文对该病例进行了讨论并回顾了相关文献。
