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Efficient constructions of disjunct matrices with applications to DNA library screening.

作者信息

Cheng Yongxi, Du Ding-Zhu

机构信息

Department of Computer Science, Tsinghua University, Beijing, China.

出版信息

J Comput Biol. 2007 Nov;14(9):1208-16. doi: 10.1089/cmb.2007.0052.

DOI:10.1089/cmb.2007.0052
PMID:17990978
Abstract

The study of gene functions requires a DNA library of high quality, such a library is obtained from a large mount of testing and screening. Pooling design is a very helpful tool for reducing the number of tests for DNA library screening. In this paper, we present two Las Vegas algorithms for efficient constructions of d-disjunct and (d ; z)-disjunct matrices respectively. These new constructions can be directly applied to construct error-free and error-tolerant pooling designs.

摘要

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