Huang Kai-Hong, Liu Jian-Hua, Wang Ling-Yun, Wang Lian-Yuan, Li Chu-Qiang, Zhu Zhao-Hua, Li Hai-Gang
Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China.
Ai Zheng. 2007 Nov;26(11):1252-6.
BACKGROUND & OBJECTIVE: For gastric stromal tumor (GST), the low incidence and high diversity in endoscopic and pathologic manifestations lead to misdiagnosis. This study was to explore the features of GST in endoscopy and clinicopathology.
Clinical data of 42 GST patients, treated at the Second Affiliated Hospital of Sun Yat-sen University from Jan. 1996 to Jan. 2006, were analyzed for their clinicopathologic and endoscopic features. The expression of CD117, CD34, smooth muscle actin (SMA), Desmin and S-100 were detected by immunohistochemistry. Their correlations to clinicopathologic features of GST were analyzed.
Of the 42 cases of GST, 21 (50.0%) were at the fundus, 14 (33.3%) at the body, and 7 (16.7%) at the antrum; 17 (40.5%) were benign, 14 (33.3%) borderline, 11 (26.2%) malignant. Endoscopically, GST presented submucosal hemispheroid or polypoid protuberant lesions with clear border. While the positive rate of gastroendoscopic biopsy was low. Of the 42 cases, 29 were spindle cell type, 5 were epithelial cell type, and 8 were mixed type. The positive rates of CD34 and CD117 were 92.86% and 78.57%.
GST has unique morphologic features. Combined detection of CD117 and CD34 benefits the diagnosis of GST.
胃间质瘤（GST）的发病率低，内镜及病理表现多样，易导致误诊。本研究旨在探讨GST的内镜及临床病理特征。
分析1996年1月至2006年1月在中山大学附属第二医院治疗的42例GST患者的临床资料，观察其临床病理及内镜特征。采用免疫组织化学法检测CD117、CD34、平滑肌肌动蛋白（SMA）、结蛋白和S-100的表达，并分析其与GST临床病理特征的相关性。
42例GST患者中，21例（50.0%）位于胃底，14例（33.3%）位于胃体，7例（16.7%）位于胃窦；17例（40.5%）为良性，14例（33.3%）为交界性，11例（26.2%）为恶性。内镜下，GST表现为黏膜下半球形或息肉样隆起性病变，边界清晰。而胃镜活检阳性率较低。42例中，梭形细胞型29例，上皮细胞型5例，混合型8例。CD34和CD117的阳性率分别为92.86%和78.57%。
GST具有独特的形态学特征。联合检测CD117和CD34有助于GST的诊断。
