Gallipoli P, Leach M
Haematology SpR, West of Scotland Deanery.
Br Dent J. 2007 Nov 10;203(9):507-9. doi: 10.1038/bdj.2007.994.
Acute myeloid leukaemias (AML) are aggressive haematopoietic neoplasms that, if untreated, can lead to death within days. Up to 40% of presenting patients show evidence of extramedullary involvement (EMI) at diagnosis. EMI is reportedly most prevalent in myelo-monoblastic and monoblastic subtypes of AML (M4 and M5 according to FAB classification) and can present as leukaemic infiltrates in many sites including gingival enlargement and mucosal and skin nodules. We report a case of a patient who presented with gingival enlargement secondary to leukaemic infiltration. This case shows the importance of awareness of leukaemic infiltration as a cause for gingival enlargement.
急性髓系白血病（AML）是侵袭性造血系统肿瘤，若不治疗，数天内即可导致死亡。初诊时高达40%的患者有髓外浸润（EMI）证据。据报道，EMI在AML的粒单核细胞白血病和单核细胞白血病亚型（根据FAB分类为M4和M5）中最为常见，可表现为白血病浸润于包括牙龈肿大、黏膜和皮肤结节在内的多个部位。我们报告1例因白血病浸润继发牙龈肿大的患者。该病例显示了认识到白血病浸润是牙龈肿大病因的重要性。
