Schrier Robert W
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA.
Drug News Perspect. 2007 Sep;20(7):447-53. doi: 10.1358/dnp.2007.20.7.1138161.
The discovery of four major water channels in the kidney, namely aquaporins (AQP) 1, 2, 3 and 4, has allowed a substantial increase in our understanding of renal water regulation in health and disease. This review discusses the renal aquaporin water channels in the urinary dilution and concentrating defects in cardiac failure, cirrhosis, syndrome of inappropriate hormone secretion, pregnancy, hypothyroidism, isolated glucocorticoid deficiency, isolated mineralocorticoid deficiency, primary polydipsia, acquired and genetic nephrogenic diabetes insipidus.
肾脏中四种主要水通道即水通道蛋白（AQP）1、2、3和4的发现，使我们对健康和疾病状态下肾脏水调节的理解有了大幅提高。本文综述了心力衰竭、肝硬化、不适当激素分泌综合征、妊娠、甲状腺功能减退、孤立性糖皮质激素缺乏、孤立性盐皮质激素缺乏、原发性烦渴、获得性和遗传性肾性尿崩症中，肾水通道蛋白水通道在尿液稀释和浓缩缺陷方面的情况。
