与裸金属支架相比，使用紫杉醇或雷帕霉素洗脱支架是否会进一步减少冠状动脉旁路移植术的需求？
Does the use of paclitaxel or rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?
作者信息
Lemos Hernani Pinto de, Atallah Alvaro Nagib
机构信息
Brazilian Cochrane Center, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil.
出版信息
Sao Paulo Med J. 2007 Jul 5;125(4):242-5. doi: 10.1590/s1516-31802007000400010.
CONTEXT AND OBJECTIVE
The safety and efficacy of drug-eluting stents reduce the need for surgical revascularization. The objective of the present study was to investigate whether paclitaxel or rapamycin-eluting stent are effective in avoiding the need for coronary-artery bypass grafting.
METHODS
This was a systematic review of the literature using the methodology of the Cochrane Collaboration. The type of study considered was controlled randomized trials; the type of intervention was drug-eluting or bare-metal stents; and the main outcome investigated was coronary-artery bypass grafting.
RESULTS
The ten studies included in this systematic review did not show any statistically significant difference between the drug-eluting stents and the bare-metal stents with regard to the outcome of coronary-artery bypass grafting (confidence interval: 0.31 to 1.42).
CONCLUSION
The surgical revascularization rate was not reduced by the use of drug-eluting stents.
背景与目的
药物洗脱支架的安全性和有效性降低了外科血管重建术的必要性。本研究的目的是调查紫杉醇或雷帕霉素洗脱支架在避免冠状动脉旁路移植术方面是否有效。
方法
这是一项采用Cochrane协作网方法对文献进行的系统评价。所考虑的研究类型为对照随机试验；干预类型为药物洗脱或裸金属支架；主要研究结果为冠状动脉旁路移植术。
结果
该系统评价纳入的十项研究显示，在冠状动脉旁路移植术的结果方面，药物洗脱支架与裸金属支架之间没有任何统计学上的显著差异（置信区间：0.31至1.42）。
结论
使用药物洗脱支架并未降低外科血管重建率。
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