Katami M
Department of Ophthalmology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Ann Acad Med Singap. 1991 Jul;20(4):433-8.
It has been known that a corneal graft can induce an allograft rejection reaction even in such an "immunologically privileged site". Reliable microsurgical techniques, together with the availability of inbred or congenic strains and a rapidly developing knowledge of its major histocompatibility complex (MHC) and immune system in general, have made the rat a prime species in which to study the immunological events after corneal grafting. This review describes recent progress in understanding the immunological mechanisms behind clinical corneal graft rejection. The topics discussed include the rat major histocompatibility complex (MHC) (RT1) antigens and their distribution in the cornea and the role of antigen-presenting cells (ARCs) in corneal graft rejection.
众所周知，即使在这样一个“免疫赦免部位”，角膜移植也会引发同种异体移植排斥反应。可靠的显微外科技术，以及近交系或同源近交系的可利用性，再加上对其主要组织相容性复合体（MHC）和整个免疫系统的快速发展的认识，使得大鼠成为研究角膜移植后免疫事件的主要物种。这篇综述描述了在理解临床角膜移植排斥背后的免疫机制方面的最新进展。讨论的主题包括大鼠主要组织相容性复合体（MHC）（RT1）抗原及其在角膜中的分布，以及抗原呈递细胞（ARCs）在角膜移植排斥中的作用。
