Dixit A, Baquer N Z, Rao A R
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Biochem Int. 1991 Jul;24(4):649-59.
Effect of exogenous 17 beta-estradiol and ovariectomy was determined on the activities of some enzymes of carbohydrate metabolism in regenerating mouse liver. 17 beta-estradiol increased liver weight and the activities of these enzymes when given after partial hepatectomy whereas ovariectomy, performed 2 weeks prior to hepatectomy, reduced the activities significantly. Estradiol administration to ovariectomized-partially hepatectomized animals restored the activities of glycolytic enzymes but not of G6P-DH and malic enzyme. This indicates that estradiol acts as a stimulator of growth of proliferating liver as it does in target tissue.
研究了外源性17β-雌二醇和卵巢切除术对再生小鼠肝脏中一些碳水化合物代谢酶活性的影响。部分肝切除术后给予17β-雌二醇可增加肝脏重量并提高这些酶的活性，而在肝切除术前2周进行卵巢切除术则显著降低了这些酶的活性。对卵巢切除-部分肝切除的动物给予雌二醇可恢复糖酵解酶的活性，但不能恢复葡萄糖-6-磷酸脱氢酶（G6P-DH）和苹果酸酶的活性。这表明雌二醇在增殖的肝脏中如同在靶组织中一样，起到促进生长的作用。
