van der Stel J C
De Geestgronden te Bennebroek.
Tijdschr Psychiatr. 2007;49(11):813-22.
The determinants and disease mechanisms of schizophrenia are largely unknown. This article discusses two genetic and two epigenetic models and examines to what extent they are capable of predicting epidemiological patterns, providing insight into the determinants and disease mechanisms, and to what extent they are based on empirical findings. The proposed litmus test is whether they are able to provide an explanation for discordance in monozygotic twins. The main lines of a synthetic model are presented on the basis of the assessments.
精神分裂症的决定因素和发病机制在很大程度上尚不清楚。本文讨论了两种遗传模型和两种表观遗传模型，并研究了它们在多大程度上能够预测流行病学模式、深入了解决定因素和发病机制，以及它们在多大程度上基于实证研究结果。所提出的检验标准是它们是否能够解释同卵双胞胎之间的不一致性。在评估的基础上提出了一个综合模型的主要思路。
