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取代呋喃基喹唑啉-3(4H)-酮的合成、抗结核及抗癌活性

Synthesis, antitubercular and anticancer activities of substituted furyl-quinazolin-3(4H)-ones.

作者信息

Raghavendra Nulgulmnalli M, Thampi Parameshwaran, Gurubasavarajaswamy Purvarga M, Sriram Dharmarajan

机构信息

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka,

出版信息

Arch Pharm (Weinheim). 2007 Dec;340(12):635-41. doi: 10.1002/ardp.200700096.

DOI:10.1002/ardp.200700096
PMID:17994604
Abstract

Some novel substituted-3-{[(1E)-(substituted-2-furyl)-methylene]amino}quinazolin-4(3H)-one (5, 6, 7) a-f were synthesized by a multi-step process. These synthesized compounds are characterized by various spectroscopic techniques and evaluated for their antitubercular and anticancer activities. Biological activity indicated that some of the title compounds are potent antitubercular and anticancer agents.

摘要

通过多步反应合成了一些新型的取代-3-{[(1E)-(取代-2-呋喃基)-亚甲基]氨基}喹唑啉-4(3H)-酮(5, 6, 7) a-f。这些合成的化合物通过各种光谱技术进行表征，并对其抗结核和抗癌活性进行评估。生物活性表明，一些标题化合物是有效的抗结核和抗癌药物。

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