Platanias L C, Ratain M J
Department of Medicine, University of Chicago, Illinois 60637.
Eur J Cancer. 1991;27 Suppl 4:S53-7. doi: 10.1016/0277-5379(91)90575-x.
Hairy cell leukaemia (HCL) is a chronic progressive disease of predominantly middle-aged men. Alpha interferon has been shown to induce significant responses in HCL patients. With interferon treatment the platelet count normalizes first, followed by the haemoglobin and neutrophil counts. The number of hairy cells in the bone marrow decreases and granulocytic, erythroid and megakaryocytic cells increase. Interferon is well tolerated with the most common side effect being a flu-like syndrome. A number of HCL patients will develop neutralizing antibodies and in these cases the chemotherapeutic agents pentostatin and 2-chlorodeoxyadenosine should be considered. Preliminary results with these agents are promising and further trials are ongoing to confirm their clinical promise.
毛细胞白血病（HCL）是一种主要发生于中年男性的慢性进展性疾病。α干扰素已被证明可在HCL患者中诱导显著反应。接受干扰素治疗时，血小板计数首先恢复正常，随后血红蛋白和中性粒细胞计数恢复正常。骨髓中毛细胞数量减少，粒细胞、红细胞和巨核细胞数量增加。干扰素耐受性良好，最常见的副作用是类似流感的综合征。一些HCL患者会产生中和抗体，在这些情况下，应考虑使用化疗药物喷司他丁和2-氯脱氧腺苷。这些药物的初步结果很有前景，正在进行进一步试验以证实其临床前景。
