Shichiri M, Fukushima H, Sakakida M, Kajiwara K, Hashiguchi Y
Department of Metabolic Medicine, Kumamoto University Medical School, Japan.
Front Med Biol Eng. 1991;3(4):283-92.
The artificial endocrine pancreas is a feedback controlled system regulating insulin delivery on a minute-by-minute basis according to measured blood glucose levels. The bedside-type artificial endocrine pancreas has been proven to be useful not only as a therapeutic tool for diabetic patients but also as an elegant research tool for investigating the pathophysiology of the disease. Recently, a wearable-type, closed-loop system has been developed, of which the breakthrough was the establishment of a needle-type glucose sensor. However, for the long-term clinical use of needle-type glucose sensors, several obstacles remain to be solved, such as oxygen dependency, biocompatibility of the membrane, etc. The most promising method for the non-invasive determination of blood glucose is infrared spectroscopy. The trend in the development of a closed-loop glycemic control system which enables perfectly physiological glycemic regulation on a long-term basis is directed to an implantable device. Much research is being conducted to realize such devices.
人工内分泌胰腺是一种反馈控制系统，可根据测得的血糖水平每分钟调节胰岛素的输送。床边型人工内分泌胰腺已被证明不仅对糖尿病患者是一种治疗工具，而且对研究该疾病的病理生理学也是一种出色的研究工具。最近，一种可穿戴式闭环系统已经开发出来，其突破在于针型葡萄糖传感器的建立。然而，对于针型葡萄糖传感器的长期临床应用，仍有几个障碍有待解决，如对氧气的依赖性、膜的生物相容性等。最有前途的无创测定血糖的方法是红外光谱法。能够长期实现完美生理血糖调节的闭环血糖控制系统的发展趋势是朝着植入式设备发展。目前正在进行大量研究以实现此类设备。
