Gabashvili I S, Grosberg A Iu, Kuznetsov D V, Mrevlishvili G M
Biofizika. 1991 Sep-Oct;36(5):780-7.
Statistical model of dsDNA packaging to icosahedral bacteriophage capsid is presented. The model describes intraphage DNA as a globule, i.e. intramolecular liquid crystal. We analyse the free energy of DNA, which has a globulized part inside the phage capsid and coil-like tail outside it. Conditions when processes of DNA movement into capsid or back are thermodynamically favorable are investigated. These processes are not accompanied with any thermal effects. It is not "all or none" type process, i.e. intermediate stable states are possible. The role of DNA interaction with the capsid inner wall is considered. The essential model abilities for qualitative explanation of experimental data are exhibited.
提出了双链DNA包装到二十面体噬菌体衣壳的统计模型。该模型将噬菌体内部的DNA描述为一个球体，即分子内液晶。我们分析了DNA的自由能，其在噬菌体衣壳内部有一个球状部分，在外部有类似线圈的尾部。研究了DNA进入衣壳或返回过程在热力学上有利的条件。这些过程不伴随任何热效应。这不是“全有或全无”类型的过程，即可能存在中间稳定状态。考虑了DNA与衣壳内壁相互作用的作用。展示了该模型对实验数据进行定性解释的基本能力。
