Paige C J, Cumano A, Wu G E
Division of Cell and Molecular Biology, Ontario Cancer Institute, Toronto, Canada.
Semin Immunol. 1991 Nov;3(6):357-66.
Multipotential stem cells have the capacity to differentiate into a variety of cell types including B lymphocytes. The development of B cells from multipotential progenitors has been the subject of numerous studies and many aspects of this transition are well characterized. However, the initial genetic events which commit a stem cell to follow the B lineage developmental pathway have not yet been discovered. In this review we examine diverse experiments which may lead to increased understanding of the important first steps in the commitment process.
