吸烟会上调人脑中的α4β2*烟碱型乙酰胆碱受体。
Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain.
作者信息
Wüllner Ullrich, Gündisch Daniela, Herzog Hans, Minnerop Martina, Joe Alexis, Warnecke Marc, Jessen Frank, Schütz Christian, Reinhardt Michael, Eschner Wolfgang, Klockgether Thomas, Schmaljohann Joern
机构信息
Department of Neurology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany.
出版信息
Neurosci Lett. 2008 Jan 3;430(1):34-7. doi: 10.1016/j.neulet.2007.10.011. Epub 2007 Oct 22.
The role of the alpha4beta2* nicotinic acetylcholine receptors (nAChR) in tobacco addiction in humans is largely unresolved. We visualized brain alpha4beta2* nicotinic acetylcholine receptors of smokers and non-smokers with positron emission tomography using 2-[(18)F]fluoro-3-(2(S)azetidinylmethoxy)pyridine, commonly known as 2-[(18)F]F-A-85380. The total brain distribution volume of 2-[(18)F]F-A-85380 was significantly increased in smokers. Statistical parametric mapping revealed that the most prominent regional differences of distribution volumes (DV) were found in cerebellum and brainstem with an increased uptake in smokers. The up-regulation of alpha4beta2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction.
α4β2烟碱型乙酰胆碱受体（nAChR）在人类烟草成瘾中的作用在很大程度上尚未明确。我们使用2-[(18)F]氟-3-(2(S)-氮杂环丁烷基甲氧基)吡啶（通常称为2-[(18)F]F-A-85380），通过正电子发射断层扫描对吸烟者和非吸烟者的脑α4β2烟碱型乙酰胆碱受体进行显像。吸烟者脑中2-[(18)F]F-A-85380的全脑分布容积显著增加。统计参数映射显示，分布容积（DV）最显著的区域差异出现在小脑和脑干，吸烟者摄取增加。通过吸烟长期暴露于尼古丁后，α4β2* nAChR的上调涉及可能在尼古丁成瘾中起重要作用的皮质下脑区。
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