Wagenlehner F M E, Niemetz A H, Weidner W, Naber K G
Department of Urology, Hospital St Elisabeth, Straubing, Germany.
Int J Antimicrob Agents. 2008 Feb;31 Suppl 1:S25-34. doi: 10.1016/j.ijantimicag.2007.07.029. Epub 2007 Nov 7.
From 1994-2005, all uropathogens cultured from the urine of hospitalised urological patients were identified and their sensitivity was tested against the most important antibiotics for the treatment of urinary tract infection (UTI). Duplicate isolates were eliminated. The following results were obtained: (i) there was no general trend of increase in resistance; (ii) certain uropathogens developed resistance to some antibiotics; (iii) vancomycin- or linezolid-resistant staphylococci or enterococci did not play a role; (iv) the lowest overall rates of resistance were found with piperacillin/tazobactam; and (v) ciprofloxacin and trimethoprim/sulfamethoxazole showed the next favourable overall activity. Adequate initial antibiotic therapy is critical in the treatment of severe UTI. Therefore, ongoing surveillance of antibiotic resistance must be performed in every institution. Additionally, it reflects antibiotic and hospital infection policies in a defined department or institution.
1994年至2005年期间，对从住院泌尿外科患者尿液中培养出的所有尿路病原体进行了鉴定，并测试了它们对治疗尿路感染（UTI）最重要抗生素的敏感性。重复分离株被排除。获得了以下结果：（i）耐药性没有普遍上升趋势；（ii）某些尿路病原体对某些抗生素产生了耐药性；（iii）耐万古霉素或利奈唑胺的葡萄球菌或肠球菌未起作用；（iv）哌拉西林/他唑巴坦的总体耐药率最低；（v）环丙沙星和甲氧苄啶/磺胺甲恶唑显示出次优的总体活性。充分的初始抗生素治疗对重症UTI的治疗至关重要。因此，每个机构都必须持续监测抗生素耐药性。此外，它反映了特定科室或机构的抗生素和医院感染政策。
