含噻吩的三芳基甲烷类化合物作为抗结核药物。
Thiophene containing triarylmethanes as antitubercular agents.
作者信息
Parai Maloy Kumar, Panda Gautam, Chaturvedi Vinita, Manju Y K, Sinha Sudhir
机构信息
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
出版信息
Bioorg Med Chem Lett. 2008 Jan 1;18(1):289-92. doi: 10.1016/j.bmcl.2007.10.083. Epub 2007 Oct 30.
PMID:17997304
Abstract
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.
摘要
通过二芳基甲醇的傅克烷基化反应，随后引入氨基烷基链，合成了一系列新的含噻吩三芳基甲烷衍生物。对这些衍生物针对结核分枝杆菌H37R(v)进行了评估，结果显示其在体外的活性范围为3.12 - 12.5微克/毫升。
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