银催化乙酰苯胺的直接苄基化反应：一种制备不对称三芳基甲烷的高效方法。
Silver-catalyzed direct benzylation of acetanilide: a highly efficient approach to unsymmetrical triarylmethanes.
作者信息
Li Yuting, Zhu Yan, Tu Guangliang, Zhang Jingyu, Zhao Yingsheng
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China
College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou 215006 P. R. China
出版信息
RSC Adv. 2018 Aug 28;8(53):30374-30378. doi: 10.1039/c8ra06780e. eCollection 2018 Aug 24.
A highly efficient silver-catalyzed dibenzylation of acetanilides by employing the benzhydrol derivatives as the coupling partners to yield triphenylmethane derivatives has been developed. Various functional groups were tolerated, leading to the corresponding products in moderate to good yields. Preliminary experimental results indicated that the silver ions activate the arene rings and the strong acid TfOH provides the carbocations.
已开发出一种高效的银催化乙酰苯胺二苄基化反应，该反应采用二苯甲醇衍生物作为偶联伙伴，生成三苯甲烷衍生物。各种官能团都能耐受，相应产物的产率为中等至良好。初步实验结果表明，银离子活化芳烃环，强酸三氟甲磺酸提供碳正离子。
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