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二苯基脯氨醇硅醚作为硝基烷烃与α,β-不饱和醛不对称催化直接迈克尔反应的催化剂。

Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with alpha,beta-unsaturated aldehydes.

作者信息

Gotoh Hiroaki, Ishikawa Hayato, Hayashi Yujiro

机构信息

Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

出版信息

Org Lett. 2007 Dec 6;9(25):5307-9. doi: 10.1021/ol702545z. Epub 2007 Nov 13.

DOI:10.1021/ol702545z
PMID:17997567
Abstract

A catalytic enantioselective direct conjugate addition of nitroalkanes to alpha,beta-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.

摘要

已开发出一种使用二苯基脯氨醇硅醚作为有机催化剂，将硝基烷烃对α,β-不饱和醛进行催化对映选择性直接共轭加成的方法。以该方法作为关键步骤，还完成了具有治疗用途化合物的简短合成。

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