使用醛对苯胺和硝基芳烃衍生物进行一锅法还原单 N-烷基化反应。

One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using aldehydes.

作者信息

Byun Eunyoung, Hong Bomi, De Castro Kathlia A, Lim Minkyung, Rhee Hakjune

机构信息

Hanyang University, Department of Chemistry and Applied Chemistry Ansan Sangrok-Gu Sa-3-Dong 1271, Kyunggi-Do 426-791, Korea.

出版信息

J Org Chem. 2007 Dec 7;72(25):9815-7. doi: 10.1021/jo701503q. Epub 2007 Nov 13.

DOI:10.1021/jo701503q

PMID:17997570

Abstract

One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using various aldehydes by Pd/C catalyst in aqueous 2-propanol solvent with ammonium formate as in situ hydrogen donor is illustrated. The reaction proceeded smoothly and selectively with excellent yield at room temperature. Our protocol presents a facile, economical, and environmentally benign alternative for reductive amination.

摘要

阐述了在水-异丙醇溶剂中，以甲酸铵作为原位氢供体，使用Pd/C催化剂，使苯胺和硝基芳烃衍生物与各种醛进行一锅法还原单N-烷基化反应。该反应在室温下顺利且选择性地进行，产率优异。我们的方法为还原胺化提供了一种简便、经济且环境友好的替代方法。