用于酮的一锅法不对称还原胺化反应的稳定预成型手性钯催化剂。

Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.

作者信息

Rubio-Pérez Laura, Pérez-Flores F Javier, Sharma Pankaj, Velasco Luis, Cabrera Armando

机构信息

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, 04510, DF, México.

出版信息

Org Lett. 2009 Jan 15;11(2):265-8. doi: 10.1021/ol802336m.

DOI:10.1021/ol802336m

PMID:19093803

Abstract

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.

摘要

报道了空气稳定的预制[(R)-联萘酚]溴化钯、[(S)-联萘酚]溴化钯、[(R)-甲苯基联萘酚]溴化钯和[(S,S)-手性双膦]溴化钯配合物在各种羰基化合物的一锅法不对称还原胺化反应中的应用，该反应能以非常高的收率和对映选择性（对映体过量<99%）生成手性胺。