Shi Weiyun, Jin Huixiang, Li Suxia, Liu Mingna, Xie Lixin
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China.
Clin Exp Ophthalmol. 2007 Nov;35(8):724-7. doi: 10.1111/j.1442-9071.2007.01618.x.
To analyse indications of paediatric keratoplasty in north China and provide information for the prevention of corneal blindness.
A retrospective study was carried out in 371 children (410 eyes) aged 14 years or younger who underwent corneal transplantation at Shandong Eye Institute between 1994 and 2005. Data of preoperative diagnoses, aetiological factors and rural or urban backgrounds were evaluated.
The study included 259 boys and 112 girls, with a mean age of 7.8 +/- 4.3 years (range 2.5 months to 14 years). Of the 410 eyes, 99 eyes (24.2%) had mechanical trauma, and 93 (22.7%) had infectious keratitis. Congenital corneal opacity developed in 53 eyes (12.9%), chemical or thermal burn in 42 eyes (10.2%) and keratoconus in 37 eyes (9.0%). There were twice as many children from a rural background as those from urban background, and an even higher proportion in the category of infectious keratitis (4.8:1). Regraft was performed in 42 eyes, of which 17 had an original diagnosis of chemical or thermal burn.
Mechanical trauma and infectious keratitis are the most common indications of paediatric keratoplasty, as well as childhood corneal blindness, in north China. Regraft occurs more often in children with ocular burns.
分析中国北方儿童角膜移植的适应证，为预防角膜盲提供信息。
对1994年至2005年在山东眼科研究所接受角膜移植的371例14岁及以下儿童（410只眼）进行回顾性研究。评估术前诊断、病因及城乡背景等数据。
研究包括259例男孩和112例女孩，平均年龄7.8±4.3岁（范围2.5个月至14岁）。在410只眼中，99只眼（24.2%）有机械性外伤，93只眼（22.7%）有感染性角膜炎。53只眼（12.9%）发生先天性角膜混浊，42只眼（10.2%）有化学或热烧伤，37只眼（9.0%）有圆锥角膜。农村背景的儿童是城市背景儿童的两倍，在感染性角膜炎类别中比例更高（4.8:1）。42只眼进行了再次移植，其中17只最初诊断为化学或热烧伤。
在华北地区，机械性外伤和感染性角膜炎是儿童角膜移植最常见的适应证，也是儿童角膜盲的常见原因。眼部烧伤患儿再次移植更为常见。
