Fraix Valérie, Delalande Isabelle, Parrache Marianne, Derambure Philippe, Cassim François
Department of Clinical Neurophysiology, Salengro Hospital, Lille University Hospital, Lille, France.
Mov Disord. 2008 Jan 30;23(2):285-8. doi: 10.1002/mds.21826.
Action tremor has been described in cerebellar, task-specific, dystonic, or Holmes tremor. We report 2 patients who developed unilateral kinetic or isometric action tremor of the upper extremity, following cervical spondylotic myelopathy and capsular ischemic stroke. Slight motor weakness and spasticity with exaggerated tendon jerks and passive stretch-induced clonus were present on the same limb. The central motor pathways lesions might have been responsible for a hyperexcitability of the stretch-reflex arc and an enhancement of the coactivation of skeletal muscles through a loss of the descending or segmental control of the spinal reflexes. The unusual topography of the symptoms, their occurrence during motion, and the similar frequency of the passive clonus and the action tremor, led us to hypothesize that both patients had prolonged action-induced clonus, mimicking action tremor. Lesions of the central motor pathways lesions might be responsible for action tremor under certain conditions.
动作性震颤已在小脑性、任务特异性、肌张力障碍性或霍姆斯震颤中有所描述。我们报告了2例患者,他们在患有颈椎病性脊髓病和囊缺血性中风后出现了上肢单侧运动性或等长动作性震颤。同一肢体存在轻度运动无力和痉挛,伴有腱反射亢进和被动牵张诱发的阵挛。中枢运动通路病变可能是由于脊髓反射的下行或节段性控制丧失,导致牵张反射弧兴奋性增高以及骨骼肌共激活增强。症状的异常分布、运动时的出现情况以及被动阵挛和动作性震颤的相似频率,使我们推测这两名患者都有延长的动作诱发阵挛,类似于动作性震颤。在某些情况下,中枢运动通路病变可能是动作性震颤的原因。