University of Alabama at Birmingham, Department of Medicine, Division of Infectious Diseases, 1900 University Boulevard, 229 Tinsley Harrison Tower, Birmingham, AL 35294-0006, USA.
Curr Infect Dis Rep. 2007 Nov;9(6):448-56. doi: 10.1007/s11908-007-0069-1.
Combination antifungal therapy has been an area of great research and clinical interest since antifungals became available decades ago, in part driven by the severe morbidity and mortality associated with invasive fungal infections. Because of the availability of newer antifungal agents including echinocandins and expanded-spectrum triazoles, interest in combination antifungal therapy for invasive mold disease, especially invasive aspergillosis, has grown. This review examines combination antifungal therapy for the treatment of yeast and molds, including current studies evaluating combination antifungal therapy in three clinically important invasive fungal infections: candidiasis, cryptococcosis, and aspergillosis. This article focuses on recent clinical data and potential future clinical directions.
联合抗真菌治疗自几十年前抗真菌药物问世以来一直是一个备受关注的研究和临床领域，部分原因是侵袭性真菌感染与严重的发病率和死亡率相关。由于新型抗真菌药物（包括棘白菌素类和广谱三唑类药物）的出现，人们对侵袭性霉菌病（尤其是侵袭性曲霉病）的联合抗真菌治疗产生了兴趣。本文综述了治疗酵母菌和霉菌的联合抗真菌治疗，包括目前评估三种临床重要侵袭性真菌感染（念珠菌病、隐球菌病和曲霉病）中联合抗真菌治疗的研究。本文重点介绍了最近的临床数据和潜在的未来临床方向。
