实验室筛选出的耐青霉素戈登链球菌分离株的适应性代价与生存受损情况。
Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
作者信息
Haenni Marisa, Moreillon Philippe
机构信息
Department of Fundamental Microbiology, Quartier UNIL-Sorge, Biophore Building, CH-1015 Lausanne, Switzerland.
出版信息
Antimicrob Agents Chemother. 2008 Jan;52(1):337-9. doi: 10.1128/AAC.00939-07. Epub 2007 Nov 12.
Abstract
Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.
摘要
用青霉素对戈登链球菌进行115次传代培养后，其最低抑菌浓度（MIC）增加了100多倍，从0.008微克/毫升增至2微克/毫升。在36次传代后已达到2微克/毫升的最高MIC，但这导致了适应性受损。尽管MIC没有进一步增加，但在额外的79次传代周期中适应性部分恢复。
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