Tsuchiya Yuichi
Department of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan.
J Biochem. 2008 Feb;143(2):155-61. doi: 10.1093/jb/mvm219. Epub 2007 Nov 12.
A characteristic feature of eukaryotic cells is the presence of nuclear envelope (NE) which separates genomic DNA from cytoplasm. NE is composed of inner nuclear membrane (INM), which interacts with chromatin, and outer nuclear membrane, which is connected to endoplasmic reticulum. Nuclear pore complexes are inserted into NE to form transport channels between nucleus and cytoplasm. In metazoan cells, an intermediate filament-based meshwork called as nuclear lamina exists between INM and chromatin. Sophisticated collaboration of these molecular machineries is necessary for the structure and functions of NE. Recent research advances have revealed that NE dynamically communicates with chromatin and cytoskeleton to control multiple nuclear functions. In this mini review, I briefly summarize the basic concepts and current topics of functional relationships between NE and chromatin.
真核细胞的一个特征是存在核膜（NE），它将基因组DNA与细胞质分隔开来。核膜由与染色质相互作用的内核膜（INM）和与内质网相连的外核膜组成。核孔复合体插入核膜以形成细胞核与细胞质之间的运输通道。在多细胞动物细胞中，在内核膜和染色质之间存在一种基于中间丝的网络结构，称为核纤层。这些分子机制之间复杂的协作对于核膜的结构和功能至关重要。最近的研究进展表明，核膜与染色质和细胞骨架动态通信以控制多种核功能。在这篇小型综述中，我简要总结了核膜与染色质之间功能关系的基本概念和当前研究热点。
