通过对羟脯氨酸衍生的二氧哌嗪进行定向氧化构建环硫二氧哌嗪。
Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines.
作者信息
Overman Larry E, Sato Takaaki
机构信息
Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92687-2025, USA.
出版信息
Org Lett. 2007 Dec 6;9(25):5267-70. doi: 10.1021/ol702518t. Epub 2007 Nov 15.
PMID:18001051
Abstract
Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.
摘要
描述了通过由近端（溴甲基）硅基引导的自由基促进的C-H键氧化对羟脯氨酸衍生的二氧代哌嗪的角次甲基碳进行官能化。这种区域选择性氧化是新合成环硫二氧代哌嗪的关键步骤。
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