Petersen M B, Wang Q, Willems P J
Department of Genetics, Institute of Child Health, Athens, Greece.
Clin Genet. 2008 Jan;73(1):14-23. doi: 10.1111/j.1399-0004.2007.00913.x. Epub 2007 Nov 13.
Many human syndromes associated with hearing loss are caused by disease genes located on the X chromosome, but few X-linked loci for non-syndromic hearing loss have been reported. Surprisingly, a Y-linked locus has been identified, representing one of the only disease loci on the Y chromosome. This study reviews the different sex-linked genes and loci on the X- and Y chromosome leading to syndromic and especially non-syndromic hearing loss.
许多与听力损失相关的人类综合征是由位于X染色体上的疾病基因引起的，但报道的非综合征性听力损失的X连锁基因座很少。令人惊讶的是，一个Y连锁基因座已被确定，它是Y染色体上仅有的疾病基因座之一。本研究综述了X和Y染色体上导致综合征性尤其是非综合征性听力损失的不同性连锁基因和基因座。
