联苯酰胺p38激酶抑制剂1：发现与结合模式
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
作者信息
Angell Richard M, Bamborough Paul, Cleasby Anne, Cockerill Stuart G, Jones Katherine L, Mooney Christopher J, Somers Donald O, Walker Ann L
机构信息
GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
出版信息
Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. doi: 10.1016/j.bmcl.2007.10.076. Epub 2007 Nov 19.
PMID:18006306
Abstract
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
摘要
联苯酰胺（BPAs）是一类新型的p38丝裂原活化蛋白激酶抑制剂。本文描述了通过基于结构的聚焦筛选发现该系列化合物的过程，并参考X射线晶体结构解释了这些化合物的结合模式。
Zotero 插件