Sciubba Daniel M, Lin Li-Mei, Conway James E, Bydon Ali, Gokaslan Ziya L, Kebaish Khaled
Department of Neurological Surgery, Johns Hopkins University, Baltimore, MD, USA.
Spine (Phila Pa 1976). 2007 Nov 15;32(24):E718-22. doi: 10.1097/BRS.0b013e31815a592c.
Case report.
To report a case and review the literature on development of scoliosis following intrathecally placed opioid pump for chronic low back pain.
Intrathecal opioid administration is a technique currently indicated for the management of chronic pain syndromes. Despite evidence of scoliosis occurring after baclofen pump insertion, there has been no evidence that development of scoliosis occurs following implantation of an intrathecally placed opioid pump for treatment of lower back pain (LBP).
A retrospective review of patients with adult onset scoliosis was performed at our institution. One patient was identified as showing significant scoliotic progression following implantation of an intrathecally placed opioid pump. Radiographs were analyzed to evaluate the magnitude and configuration of her kyphoscoliosis following pump insertion.
A 50-year-old woman with intractable LBP underwent placement of a spinal cord stimulator (SCS) followed shortly by removal of the SCS and placement of an intrathecal opioid pump. Five years later, she presented with severe kyphoscoliosis involving a left thoracolumbar curve of 84 degrees and sagittal balance of 158 mm. Because of intractable pain and progressive deformity, she underwent multilevel osteotomies, instrumented fusion, and replacement of her Dilaudid pump. Postoperative radiographs demonstrated a residual 23 degrees thoracolumbar curve with restoration of her sagittal alignment. No major morbidity/mortality occurred with treatment.
Although there may not be a direct correlation between implantation of an intrathecal opioid pump with subsequent development of adult onset scoliosis, deformity must be considered a potential sequela in patients treated with such neuromodulation.
病例报告。
报告一例病例并回顾鞘内植入阿片类药物泵治疗慢性下腰痛后脊柱侧弯发展的相关文献。
鞘内给予阿片类药物是目前用于治疗慢性疼痛综合征的一项技术。尽管有证据表明巴氯芬泵植入后会发生脊柱侧弯,但尚无证据表明鞘内植入阿片类药物泵治疗下腰痛(LBP)后会出现脊柱侧弯。
在我们机构对成年起病的脊柱侧弯患者进行回顾性研究。一名患者被确定在鞘内植入阿片类药物泵后出现明显的脊柱侧弯进展。分析X线片以评估泵植入后她的脊柱后凸侧弯的程度和形态。
一名50岁患有顽固性下腰痛的女性接受了脊髓刺激器(SCS)植入,随后不久移除了SCS并植入了鞘内阿片类药物泵。五年后,她出现严重的脊柱后凸侧弯,左侧胸腰段弯曲84度,矢状面平衡158毫米。由于顽固性疼痛和进行性畸形,她接受了多级截骨术、器械融合术,并更换了她的氢吗啡酮泵。术后X线片显示残留23度胸腰段弯曲,矢状面排列恢复。治疗过程中未发生重大并发症/死亡。
虽然鞘内植入阿片类药物泵与随后成年起病的脊柱侧弯发展之间可能没有直接关联,但在接受此类神经调节治疗的患者中,畸形必须被视为一种潜在的后遗症。